Research Projects - Aging
Healthy aging and associated health risk factors are an
important focus of PHREI research. PHREI research looks
at factors and trends across populations to provide insight
into healthy aging. This includes the cancer screening trials
and studies on neurodegenerative disorders. Disorders associated with aging are an important area for research
with veterans and their families.
The cancer screening studies at PHREI provide an opportunity
to track participant's health over time and look at the
association with demographic, occupational, lifestyle, and
genetic information collected about these participants.
Collaborations with other national and international sites
allow comparisons between different populations to further
our understanding of factors influencing healthy aging.
PHREI investigators work with the Honolulu Asia Aging Study (HAAS) at Kuakini Medical Center under the direction of Dr. Lon White, to study diseases associated with aging such as Alzheimer's disease, vascular dementia, and Parkinson's disease. Several PHREI studies are complimentary to the HAAS and involve research on brain structure at death.
Genetics of Telomere Dynamics in Okinawans
This study will investigate how genes affect the ability of cells within the human body to continue dividing as they age and contribute to human healthspan. This study focuses on understanding human telomeres, which are located at the ends of the chromosomes of our bodies’ cells and tell the cells when to stop dividing. When cells stop dividing they die and this can affect the health of all tissues of the body. This, in turn, may affect the rate of aging and the risk for development of age-related diseases, such as heart disease and dementia.